![]() ![]() HDL particles remove fats and cholesterol from cells, including within artery wall atheroma, and transport it back to the liver for excretion or re-utilization thus the cholesterol carried within HDL particles (HDL-C) is sometimes called "good cholesterol" (despite being the same as cholesterol in LDL particles). This is often contrasted with the amount of cholesterol estimated to be carried within low-density lipoprotein particles, LDL, and called LDL-C. In healthy individuals, about 30% of blood cholesterol, along with other fats, is carried by HDL. the cholesterol associated with ApoA-1/HDL particles. Testing īecause of the high cost of directly measuring HDL and LDL ( low-density lipoprotein) protein particles, blood tests are commonly performed for the surrogate value, HDL-C, i.e. However, recent investigations have shown that very high concentrations of HDL particles can be associated with an increased mortality risk and an increased cardiovascular risk, especially in hypertensive patients. HDL particles are commonly referred to as "good cholesterol", because they transport fat molecules out of artery walls, reduce macrophage accumulation, and thus help prevent or even regress atherosclerosis. Increasing concentrations of HDL particles are associated with decreasing accumulation of atherosclerosis within the walls of arteries, reducing the risk of sudden plaque ruptures, cardiovascular disease, stroke and other vascular diseases. The lipids carried include cholesterol, phospholipids, and triglycerides, amounts of each are variable. Unlike the larger lipoprotein particles, which deliver fat molecules to cells, HDL particles remove fat molecules from cells. Lipoproteins are divided into five subgroups, by density/size (an inverse relationship), which also correlates with function and incidence of cardiovascular events. HDL particles enlarge while circulating in the blood, aggregating more fat molecules) and transporting up to hundreds of fat molecules per particle. They are typically composed of 80–100 proteins per particle (organized by one, two or three ApoA. Lipoproteins are complex particles composed of multiple proteins which transport all fat molecules ( lipids) around the body within the water outside cells. High-density lipoprotein ( HDL) is one of the five major groups of lipoproteins. One of the five major groups of lipoprotein ![]()
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